Revealing mistake: When Sheldon goes to Penny's apartment and they do a scene study together, they both read lines from a multi-page script that Sheldon brings with him. On a couple of occasions the camera cuts to a side view of Sheldon and we get to see the page of the script that he's currently reading from. The pages are completely blank.
Character mistake: In his conversation with Missy Sheldon makes it clear that his superior intelligence is a result of a random, mutated gene. Since Missy isn't similarly intelligent she obviously isn't carrying this mutated gene (which would be a billion to one shot anyway) so her offspring wouldn't inherit it. Sheldon would know this - his offspring would carry the mutated gene for superior intelligence, Missy's would not. Anyone knowing enough about genetics to use the term 'randomly mutated gene' understands enough to know that the mutated gene would only be expressed in a direct line from the carrier - Sheldon. Also bear in mind he has a model of the DNA molecule in his living room - it is obviously an interest.
Trivia: In this episode, Sheldon and Amy are trying to decide on couples' themed Halloween costumes. Sheldon is standing in front of the dry erase board. There are 2 columns written on the board. One named "Couples I Like" and the other "Couples You Like." Under the "Couples You Like" column, one of the couples is Blossom and Joey. Blossom is the name of the television character played by Mayim Bialik in the 90s and Joey was one of her brothers.
Question: Though it comes up in other episodes as well, this one is focused on Sheldon needing a ride everywhere he goes because he can't drive, not to mention his not being welcome on the bus. Of course, this story element would be nonexistent if there was a simple answer, but it does beg the question: Does Pasadena not have taxicabs?
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