Corrected entry: After Sheldon has told Barry about the rules of Rock/Paper/Scissors/Lizard/Spock for the first time, Barry then replies "I'm sorry, can you repeat that." When he says "repeat", he correctly pronounces the "r." However, it has already been established throughout the series that Barry pronounces all his Rs like Ws due to his speech impediment.
Corrected entry: Five minutes into the show, Sheldon has written down what a dice roll will tell him what to do. He rolls the dice, pauses and looks at the list to see what he has to do for that dice roll. The problem is he has an Eidetic memory and wouldn't take the time to look at the list when he can already see it in his head.
Corrected entry: Leonard and Penny are inhaling Sulphur Hexaflouride to make their voices low. The effect can be seen to be fake for two reasons. First, their voices go back to normal instantly and on demand - the gas actually takes a while to clear. Second, when Leonard releases the balloon, it flies away; it should just fall to the floor because Sulphur Hexaflouride is heavier than air.
Corrected entry: After Amy stalks off on Sheldon, Penny tells him off because she told him some good news about her paper being published, and he belittled her achievements while bigging up his own, trivial activities. She is very specific about what he did and why Amy reacted. How did she know all of this? She was nowhere near the table at the time and could not possibly have overheard their conversation. She might assume Amy is mad at Sheldon but she can't possibly know why.
Corrected entry: Stephen Hawking tells Sheldon he made an arithmetic mistake on page 2 of his paper. Sheldon then quickly turns pages on his paper to find the error, but Sheldon turns several pages of his paper, way past the second page, and still finds the error Stephen had noted.
Corrected entry: In 3-14 "The Einstein Approximation" Bernadette stated that she is able to easily handle children as her Mother ran an illegal day care centre in their basement. However, in this episode she states that she hates children because her mother worked and she had to bring up her siblings, and she cannot properly react to children. So which is it? Can't be both.