Plot hole: In Series 1, Episode 7, "The Dumpling Paradox, " Sheldon makes an oblique reference to his financial status: "Frankly, if I could afford the rent, I'd ask you [Leonard] to leave, " meaning he cannot pay the rent on his two bedroom apartment by himself - not that he doesn't want to, he can't. However, in "The Execlsior Acquisition, " we find that he does not even cash his pay cheques. He doesn't even deposit them into a bank account - he leaves them in a drawer in his desk. In Series 2 Episode 14 "The Financial Permeability", he lends Penny a large amount of money from a huge bankroll he just happens to have lying about - again, without cashing his pay cheques! He is obviously independently wealthy. Either he doesn't have enough money to afford the rent or he has enough to work without being paid while practically giving large amounts of cash away. Can't be both.
Factual error: There is not a snowball's chance of Howard becoming an astronaut. He suffers from cardiac arrhythmia, something about which he is completely open. "Transient" or not this is easily detectable by a simple electrocardiogram, which is a fundamental part of the many medical examinations a potential astronaut will have to pass. He wouldn't even be allowed to start basic training. Note also that during his basic training he shows signs of severe stress and trauma which would inevitably trigger a cardiac episode. Even if it didn't the fact that he was falling apart at the seams would have him removed from the programme for his own good.
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