Factual error: When House is looking over his whiteboard of symptoms for the swimming patient, the symptom "Intercranial Hemorrhage" is shown on the board. However, this is an error. The correct term is "Intracranial Hemorrhage." Anything inside the head is referred to as "intra" not "inter." This is a common mistake for laypeople, however the highly trained and knowledgeable Dr. House should not have made that error. (00:31:25)
Factual error: House's team listed the potential offending organisms of the infection as "MRSA, H. Flu, VRE, and pseudomonas." House then suggests Vancomycin and Aztreonam. Vancomycin only covers gram (+) organisms and Aztreonam only covers gram (-) organisms. VRE is a gram (+) organism, thus it would not be covered by Aztreonam. VRE stands for vancomycin resistant enterococcus, thus it would not be covered by Vancomycin either. House's team therefore failed to cover for an offending organism that could have caused the infection during their initial differential. (00:09:10)
Factual error: House is playing 'Metroid: Zero Mission' on his Gameboy at various times. The Metroid series does not feature space monkeys, nor are there distinct levels. The sounds coming from the game in the show do not match it in real life, and Samus morphing into a ball is most definitely not a failure state.
Continuity mistake: As House describes the lady's symptoms, in the front shot Chase has a small book/pamphlet in his hand. The camera changes to a side shot in the middle of House's description and suddenly the book is on the table and no longer in Chase's hand. This happens right in the middle of House's line and Chase doesn't make any quick movements to account for this discrepancy.
Revealing mistake: Exactly ten minutes to the end, the couple with the baby Maxine are waiting to hear how she is doing. The mom and the husband are sitting on a bench outside the room in which their daughter is being treated. The mom lies down on her husband. She is supposed to have given birth only recently, so she still has a big tummy. As she lies against her husband, however, it is clear that she is wearing a prosthetic stomach: her blue T-shirt tucks and crinkles into and around it in a way that shows it is not an organic part of her.
Continuity mistake: During the scene where Dr. Chase and Dr. Cameron are out having a drink, Cameron picks up Dr. Foreman's cell phone. Before she does she takes a drink of her soda. This drink drops the level of drink to half full. When Foreman returns a few seconds later she suddenly has a glass that is 3/4 full. There was no time for anyone to give her a refill. (00:18:55)