Other mistake: In the last episode of season 1, Lucas goes to see Haley and Nathan where they tell him they got married last night, which must have been after the playoffs game. However, in season 2 in flashbacks of their wedding they got married during the day.
Character mistake: Lucas is seen placing flowers on Keith's tombstone, which states he died on January 23, 2006. In the next shot Lucas places a single flower on the grave of Jimmy Edwards, who died the same day and in the same scene as Keith, yet his tombstone states that he died on March 1, 2006.
Continuity mistake: In the beginning of the series, Haley's big family is brought up often, implying that she has 3 brothers and 3 sisters. When her mom visits her, Taylor and Quin to announce that she is dying, there is no mention of or visit from any other siblings and Lydia talks about those 3 as if they are her only children.
Plot hole: How in the world could Keith be hired as a teacher? Not only is he a college drop-out with no teacher training, Dan mentions just an episode or two earlier how Keith is incapable of using modern machinery (specifically saying how every high school graduate will be more qualified than Keith).
Plot hole: When Dan asks Lucas how he managed to lie to Karen about his heart test results then successfully move out, Lucas tells Dan that he showed Karen Keith's test results letter instead. In a prior scene, Lucas hands Karen the results letter and she is elated to read no Hypertrophy issues. Being a very savvy business woman, Karen would have noticed the addressee on the letterhead was Keith, NOT Lucas.
Continuity mistake: When Lucas is with Keith at the graveyard in 4-10 and Brooke is standing in front of "Peyton's" tombstone, it says she died on March 1, 2006. Keith notes that she died on the day of the shooting. However in this episode Lucas visits Keith's grave where his tombstone says he died in January 2016.