Continuity mistake: Both the positive and negative versions of Lazarus have a long mustache and a fairly full "waterfall" beard - until the scene in the briefing room, when inexplicably, the mustache and beard are both suddenly so thin they're barely visible. As soon as they beam down to the planet, however, the much thicker facial hair is restored. (00:23:00 - 00:24:30)
Continuity mistake: Mad Lazarus has just put a black-and-white hatch cover over the stolen dilithium crystal in his time ship. It's in place when Kirk arrives to confront him. But a moment later, when Kirk leans in and is accidentally transported to the negative universe, the cover has disappeared. It's still missing when Kirk returns to push Lazarus through the portal. (00:39:20)
Plot hole: Kirk knows that Lazarus is insane and that he wants the Enterprise dilithium crystals. Yet he's not restrained in sickbay and is, in fact, given free run of the ship so that he can knock out the crew in engineering and steal the crystals. Other than to further a woefully weak plotline, this makes no sense whatsoever.