Audio problem: When Peter introduces the pope to his friends at work, and he is saying "Remember when we got that stripper for Charlie and it turned out to be his son? I think this is gonna top it" or something along those lines), Peter's mouth very obviously does not sync up with the words being said.
Audio problem: When Peter goes down to the basement, the Pawtucket Patriot guy appears and Peter thinks he's coming on to him. He says, "Listen, I don't swing that way, pal. I got a date with my female wife, I just came down to get some beers." However, his lips very obviously do not sync up with those words.
Audio problem: After Lois goes insane and jumps out the window, she insults Frosty the Snowman, who then goes up to her to demand an apology. Lois then takes out a match and uses Frosty's nose to light it. Frosty recoils, holding his nose and saying "Ow, ow, what the-" but it cuts to a shot of Lois grabbing a bottle of beer from a hobo as Frosty is saying "What the" and it shows him standing perfectly straight, with his mouth not moving at all.
Audio problem: Just after Peter graduates from the Police Academy, he goes home to Lois and draws his gun in the kitchen, which gets Lois very excited. Every time Peter fires his revolver, you'll hear a soft, but distinctive clink briefly after each shot. This clink comes from shell casings hitting the floor, which revolvers make impossible. Revolvers are designed to eject expended shell casings only while its user is reloading, not after each shot is fired. Only semiautomatic firearms immediately eject expended cartridges immediately after having been fired. Unless I'm mistaken, the entire gunshot sound originally came from a 9mm semiautomatic pistol.
Audio problem: Neil uses a tape recorder to record Meg, and the recording can be heard to say "Give it to me. Give it to me Neil" however the actual dialog when spoken included a line by Neil between the end of "Give it to me" for the first time and before the second. Which isn't in the playback. (00:07:30)