Continuity mistake: Before Homer sees his vision of Caesar Romero the day sign next to him says 9. After the Duff executives see him talking to nobody they decide to take him away and when they get down there the sign now says 12 with the president of Duff confirming it in his speech. Doubtful it took them 3 days to get down to him and not much reason for Homer to take 3 days off the sign seeing as he was almost passing out from the lack of food.
Continuity mistake: There are two problems with Lisa's Indian burns. When we first see them, she has 4 burns. Then, while she is showing them to the bullies, there are 3, then 4 again. Then, in the very next scene when she is walking with Nelson in the schoolyard, they are gone altogether.
Continuity mistake: When Lisa is watching tapes of Francine's bullying, there is a scene where they are at the pool. Francine is wearing nose clips in this scene. But when Lisa freeze-frames and leans in to closer inspect the shot, Francine's face is shown on the screen without nose clips. They appear again when Lisa exclaims "Of course. The nose clips."
Continuity mistake: When the Simpsons are on the raft going down the river in Africa they come to a fork and have a choice of going to the left, towards a sunny and nicer area or to the right where it is rainy and gloomy. As Homer tries to steer the raft to the left as he pulls his left arm out of the water and it is covered in leeches but in the next shot of him when we see the arm again the leeches are gone. No way to remove leeches that fast.
Continuity mistake: During Lisa's and Bart's segment, time seems to run really quickly. When Lisa leaves West Springfield Elementary it is 11:00 and when she gets to Moe's it is noon, then a few minutes later it is 2:50. When Bart and Milhouse find Fat Tony it is noon, then when Bart gets hit by the truck, it is almost 3:00.