Continuity mistake: During the "performance" at the end of Marge's book, "Ned" is skewered by a harpoon and falls off the cliff. When "Homer" walks up to the cliff edge you can no longer see the rope trailing from the end of the harpoon. However, moments later he gets his leg caught up in it and is pulled over himself.
Plot hole: Dr Marvin Monroe says to Marge he was gone for a long time because he was sick. That's impossible because he died in a previous episode and you can even see his tomb in the episode where Maud Flanders dies. [It could be argued that Monroe really was sick. It was never explained how he died and no one mentioned that he really was dead. The grave, the hospital named after him were in the simpsons universe with the belief he was dead. The clip show mentioned his death but alluded any specifics. As Marge mentions she thought he was dead and so could everyone else on the show.]
Continuity mistake: When Marge is typing her novel on the computer, in one close-up shot of her we see there is a pencil on one side of the table and a pot of flowers on the other. Yet when the shot changes to further away we can see that the pencil has been replaced by a napki, a pot with two pencils has appeared, and the flowers have moved to this side of the table as well. (00:06:20)
Continuity mistake: After the clown balloon that rips at the car dealership there is a bit of material left over and there is also a cord attached to the wooden platform where the balloon was. After a reaction shot, it cuts back and the material and the cord have both disappeared.
Plot hole: When Marge is looking for inspiration for her novel, she looks at the boat painting in the TV room. On the frame, she reads it and says: "Scene from Moby Dick". Yet in "The Trouble With Trillions", Marge said that she painted it herself for Homer. So then why would she have to read the label to find out where it's from if she painted it?
Continuity mistake: When Homer goes to Ned to make sure Marge imagines nothing again, Homer puts his hand through the door, then he puts his hand through the mailbox, then Nelson puts his hand out to steal the doormat. Nelson puts his hand just over the mailbox, then in the next shot when it reveals Nelson is there, his hand is suddenly under the mailbox without enough time to move it.