Continuity mistake: The location of the comet in the sky changes direction at several points. Whilst it's apparent size and altitude will of course change, the direction it is coming from cannot. As an example, it is seen looming over the power plant towers, but when Ned is on the hill, it's no longer there.
Continuity mistake: When Mr. Burns pushes the child on the swings, he somehow manages to defy the laws of physics. When he pushes the child forward for the last time, he swings forward, then back, hitting Mr. Burns in the head. He then swings forward again, hitting Mr. Burns from behind. Mr Burns starts saying "You've won this round..." and the child then hits Mr. Burns from behind again. In order for this to happen, he would have to go completely around between the second and third hits and you clearly see he doesn't.
Continuity mistake: In the scene where Bart tries to get his radio back from the well, watch the police barriers. When Lou and Eddie get coffee, they walk through one of the barriers, tearing it. Several shots later, this torn piece has vanished, and then the barriers disappear entirely. (00:15:40)
Continuity mistake: When Sadgasm is making their first appearance, Homer says, "We are Sadgasm," and there are a few students walking around, but when he says, "And this song is called 'Politically INcorrect'," there is a big crowd in front of them with no time to form one.