Character mistake: When Aram wears the CDC hazmat suit, the CDC personnel advises Aram that he has 20 minutes of air to keep him alive, making the mission time critical. What she says additionally is that "oxygen levels plummet and carbon monoxide (CO) levels rise" CO is not a byproduct of human respiration - carbon dioxide is.
Factual error: Norfolk Naval Base is located on completely flat terrain and the areas around the base is devoid of trees in all directions for miles. The scene shows the ship with a tree-filled hillside across the water. Obviously the scene was not shot in Norfolk, VA. (00:32:08)
Character mistake: Reddington says that the 1943 pennies he is hunting are special because they were made of bronze when all other pennies were made of copper. The 1943 pennies were actually the steel pennies from WWII as to save copper for the war efforts, there were some copper errors that year, but the majority were zinc and not copper.