Factual error: There is not a snowball's chance of Howard becoming an astronaut. He suffers from cardiac arrhythmia, something about which he is completely open. "Transient" or not this is easily detectable by a simple electrocardiogram, which is a fundamental part of the many medical examinations a potential astronaut will have to pass. He wouldn't even be allowed to start basic training. Note also that during his basic training he shows signs of severe stress and trauma which would inevitably trigger a cardiac episode. Even if it didn't the fact that he was falling apart at the seams would have him removed from the programme for his own good.
Character mistake: In his conversation with Missy Sheldon makes it clear that his superior intelligence is a result of a random, mutated gene. Since Missy isn't similarly intelligent she obviously isn't carrying this mutated gene (which would be a billion to one shot anyway) so her offspring wouldn't inherit it. Sheldon would know this - his offspring would carry the mutated gene for superior intelligence, Missy's would not. Anyone knowing enough about genetics to use the term 'randomly mutated gene' understands enough to know that the mutated gene would only be expressed in a direct line from the carrier - Sheldon. Also bear in mind he has a model of the DNA molecule in his living room - it is obviously an interest.
Factual error: Raj and Sheldon are watching TV in Raj's apartment and we hear music playing. Sheldon asks if the woman on TV was Aishwarya Rai to which Raj says yes and then they argue about her and Madhuri Dixit. The song playing was from the Bollywood movie Kaho Na Pyar Hai, but neither of them are in the movie - the lead actress was Ameesha Patel. (00:14:50)
Trivia: In this episode, Sheldon and Amy are trying to decide on couples' themed Halloween costumes. Sheldon is standing in front of the dry erase board. There are 2 columns written on the board. One named "Couples I Like" and the other "Couples You Like." Under the "Couples You Like" column, one of the couples is Blossom and Joey. Blossom is the name of the television character played by Mayim Bialik in the 90s and Joey was one of her brothers.
Question: Though it comes up in other episodes as well, this one is focused on Sheldon needing a ride everywhere he goes because he can't drive, not to mention his not being welcome on the bus. Of course, this story element would be nonexistent if there was a simple answer, but it does beg the question: Does Pasadena not have taxicabs?
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