Continuity mistake: When Tom the Minion dressed as a maid is hoovering, he answers the front door by opening it towards him as does the minion who looks out of the door after Tom has been taken. In the scene with Gru sat on the steps in the rain, sad that Lucy is off to Australia, Agnes comes out with an umbrella, but now the door opens outwards.
Continuity mistake: When Doctor Nefario is having a send off, he begins to blast off in his scooter very slowly. The shot after he says "This may take a while", the Minions begin to leave the area, yet in the next shot, the other Minions have vanished completely. There was nowhere near any time for them to have left the area that quickly. (00:21:10)
Continuity mistake: When Gru is making balloons with his balloon gun thing he attaches an inflated unicorn balloon to the door frame and an exterior shot of the front lawn is shown. This shot shows a playhouse on the right hand side of the lawn. Later on, when Lucy arrives at the house, the playhouse is no longer on the lawn. (00:03:30 - 00:07:45)
Continuity mistake: In the opening scene at the Arctic Circle, two of the workers are shown playing poker. The player on the right pushes the coin pile to the left side of the container. A couple of shots later, after the player on the left has claimed victory, the coin pile has suddenly moved to the middle. (00:01:35)