Continuity mistake: In the scene when Train 777 is coming straight at the passenger train with the kids, the train is coming straight at them (just a single track). But a few shots later, a rip track leading to a siding comes out of nowhere without being seen. (00:23:05)
Continuity mistake: When Dewey and Gilleece are attempting to jump aboard the runaway train by driving along side its front cab, the passenger side door is ripped off by crashing into a train signal. In one shot the door is still partially attached to the vehicle and trailing on the ground. But in the next shot the door is gone and nowhere to be seen on the ground behind. (00:25:05)
Continuity mistake: After the double train fails to slow train 777 and gets switched to another section of track, in the control room, you see the train has already partly gone around a bend on the TV screen behind the bearded character, then cuts to the TV report footage which shows the train continuing on for a few seconds, though when the scene cuts back to the train, it is only just beginning go around the same bend that it had already partly travelled. (00:45:20)
Continuity mistake: After the loco connects to the back of the train, a couple of scenes show the engine with the air hoses connected, and some do not. These hoses can only be connected from ground level.
Continuity mistake: In the scene where the train hits the horse trailer, it knocks its left side light out. However each scene after that showing the train it has its right side light broken.
Continuity mistake: The horse trailer is shown sitting across the track, but when they are unloading the horse the back of the trailer is facing along the track.
Continuity mistake: In the big finale where Ned is racing alongside the train in his truck and picks up Colson, they have said that the 777 is at 75 mph and gaining speed toward 80. Yet the view of Ned's speedometer shows him just getting to 70 mph while he is passing the train. To be passing the train he would have to have been in the 90-100 mph range.
Continuity mistake: Change in the number of cars 1206 is suppose to haul. In the beginning of the film Frank and Will are in a truck with other engineers. Frank asks Will what the daily list is. Will responds that they are suppose to pick up 25 cars. After they pick up the cars and are leaving the yard, Frank notices they have too many cars. He points this out to Will and asks how many cars they are suppose to get and Will says 20 (not the 25 he said earlier) Will says he counted 5 too many cars. Then they talk about the 25 they have that is incorrect it should be 20.
Continuity mistake: One of the shots in the scene where the runaway passes the Railroad Safety Campaign shows 777 speed by the campaign train's window. In this shot, the numbers 777 are painted backwards.
Continuity mistake: When Dewey and Gilleece are in the rail roller truck, the tailgate of the truck is clean with nothing on it. After the attempt to climb on 777 fails and the door gets smashed off, the tailgate suddenly has some kind of equipment either attached to or exposed off the tailgate in the middle.
Continuity mistake: Near the beginning of the movie, we learn from Dewey talking to Connie that train 777 is pulling 39 cars. At the end of the movie, we see a front view of 777 stopped on the tracks. The tracks extending back from the locomotive curve off to the right and you can see the rail cars all the way back to the blue locomotive 1206. There is nowhere close to 39 cars between locomotive 777 and locomotive 1206.
Continuity mistake: When the truck with the horse trailer is across the crossing, 777 is way off in the distance with a deer crossing the tracks. The next shot of 777 shows the train a lot closer to the crossing and then in the final shot, it shows 777 way in the distance again, showing the same deer crossing the tracks.