Corrected entry: The setting for the movie is Mississippi. At the beginning, as Michael Oher's character is being driven to another school, you'll notice that there is a real estate sign as the shot shows him looking out the window. The real estate sign had a 770 area code. That area code is in Georgia, not Mississippi.
Corrected entry: When Oher is blocking 66 in his first game, as he drives him "to the bus", in the middle of the play his number appears to change from 66 to 56.