Continuity mistake: When Darby is running from the police and heading for the police car you can see the exhaust emitting from the police cruiser tail pipe. When he gets in the car he says start the car and you can see Clyde turn the ignition/keys and the engine starts of an already idling vehicle. (00:20:35)
Other mistake: After killing his inmate, notice the blood on the inmate's neck is present in great amount. After camera changes, the blood is only on the shirt, the neck is clean with no holes nor coagulated blood. (00:51:00 - 00:51:45)
Audio problem: As Shelton is about to drive away from City Hall, we see him operate a lever on the steering column of the van and we hear the familiar sounds of a transmission shifter clunking through a few settings into "Drive". The problem is that he used the lever on the left side of the column, which is the turn signal lever. The transmission shift lever is on the right side of the column. In reality, Butler used his left turn signal before steering left into the travel lane, and the sound editors added the shifter sound to try and cover the fact he's never actually seen putting the van into gear in the scene. (01:31:50)
Other mistake: When Clyde is in the van driving back to the prison he encounters a road block. He evades this by driving down into the parking garage. There's no way that the police or SWAT would have missed this loophole. (01:32:34)
Plot hole: Inmediately after Jamie Foxx finds the bomb in the city hall, and he says, "We don't tell the mayor anything", we see Gerard Butler arriving to his property next to the prison, and finally he enters his jail cell. So, in the time between Gerard Butler's arrival to the property and his entrance to the jail cell, Jamie Foxx thought about a plan, picked up the bomb, passed through the traffic and security checkpoints, talked to the warden to get access to the prison, entered solitary, handcuffed the bomb, and still had time to wait for Gerard Butler's arrival.
Character mistake: In the court scene Clyde mentions a case, Day v McDonough docket number 04-1325. This is a real case, but the docket number is 04-1324.
Factual error: In the scene when the police are heading to Clyde's house to arrest him, this tactic is highly unrealistic. In real life, when a person is simply a suspect in an investigation, the police do not all drive to the suspect location with lights and sirens going. This loses the element of surprise. They didn't even know if he was home, anyway.
Plot hole: When Clyde leaves the building that he has planted the bomb to kill the Mayor and the rest of her party, he goes to his van, watches a TV feed of the meeting, then puts the van into gear and moves off. Only problem is, he didn't actually switch on the ignition, and no, Clyde didn't leave the van left switched on either, he's meticulously planned the whole operation, and isn't likely to chance his one means of escape by allowing it to be so easily stolen, and any suggestion that he'd be able to leave the van running with 'conspicuous police security' is a nonsense, as that would draw more attention to the van, something Clyde SPECIFICALLY would not want.
Character mistake: Clyde enters his cell in the final scene, and is surprised to find that he has been found out. His secret tunnel, if we go according to the characteristics accredited to his character throughout the movie, is surprisingly without any alarms of any sort. Very strange if we are to believe he is as deadly as credited. He ends dying a very silly death.
Factual error: The co-ordinates given by Clyde Shelton: 39° 57' 4"N 75° 10' 22W as the place to find Mr. Reynolds, is the corner of 19th and Sansom Street in Center City (1919 Sansom, to be exact, which is an apartment complex), the downtown area of Philadelphia. The scene actually takes place underneath of the Betsy Ross Bridge, about 8 miles northeast of the coordinates.
Factual error: In the cemetery scene when the SUVs are leaving and the EMP knocks out electrical systems, the next thing you hear is walkie-talkie communucations between the vehicles. Those would've been knocked out, as well.
Factual error: During the lethal-injection scene, an executioner is plainly visible to the witnesses through a broad glass window in the death chamber. He is shown flipping toggle switches in-sequence to release the sodium thiopental, pancuronium bromide and potassium chloride that comprise the lethal drug cocktail. For one thing, in modern Western culture, an executioner is never visible to the witnesses. For another thing, there is no "executioner," per se, flipping toggle switches in the lethal-injection process. The component drugs are loaded into the death machine in advance, and it automatically releases the drugs via a pre-set timer.
Audio problem: When Nick and the others are flying in a helicopter to find the buried lawyer, not only does the registration number of the helicopter change, but the model is a Bell 206 L-4. As it flies along, you hear the sound of the chopper going by. The sound of the helicopter dubbed in is of an American Eurocopter aircraft with a Fenestron instead of a tail rotor. These two aircraft have a completely different sound.
Visible crew/equipment: This is only visible in the unrated version and not the theatrical version due to different shots. When Clyde is stabbing his cellmate, a crew member is visible in the left side of the screen for a second.