Continuity mistake: When Vince leaves the freezer and is making his way onto the elevator, he is carrying a Baretta model pistol. When he shoots as the elevator doors are closing the camera cuts to a Glock model pistol, then back to the Baretta again. When the elevator reaches the upper level, the woman picks up the remains of the backfired pistol and it is back to the Glock. (01:21:15 - 01:24:30)
Factual error: When J.D. gets killed, Vince's leg shakes. Vince is suppose to be paralyzed. Even if he was extremely scared, his leg shouldn't have been able to move no matter how much he tried. It happens again later in the movie. (00:30:55)
Visible crew/equipment: In the scene where the team are searching for the killer, an overhead shot of the town shows some sort of a rain-making machine in the upper right hand corner of the screen.
Continuity mistake: After Nicole smokes her last cigarette (literally), and starts to decompose, the blood stain on her chest changes in size. At first, it is pretty big and on only one side. In the next shot that she is in, the blood stain separated causing a small stain on one side of her chest, and a slightly larger stain on the other. (01:08:40)
Visible crew/equipment: When we see the outside closed circuit television camera for the second time (the first is when the agents come on to the island) the cameraman filming the scene is reflected in the CCTV camera's lens. (00:26:05)
Factual error: At the end when the two people are shooting at each other underwater, they both fire about four shots at each other. This isn't possible because a gun needs pressure to reload, or else it would jam after one or two shots. An episode of Mythbusters confirms this.
Factual error: Liquid nitrogen comes in a stainless steel Dewer Flask, which is a larger diameter than shown in the film. The gas cylinders shown, on two occasions, are the type used for high pressure gas, not liquid nitrogen. (00:17:10)
Other mistake: When the remaining agents are sitting at tables drinking coffee, Vince glances up at the clock which says 12h00. He then says "It's two o'clock and we're still here. We're still here and it's two o'clock." (00:37:30)
Revealing mistake: When Gabe fights with Lucas, if you look closely the entire time "Lucas" is actually a stunt double.
Factual error: J.D's legs wouldn't be frozen and shattered in seconds by liquid Nitrogen spray. In fact, science has shown that even fully submerging a leg in LN2 for 30-40 seconds will only freeze the surface. Which will then thaw after several minutes. (00:31:38)
Visible crew/equipment: In the fight scene on the staircase the crew that is filming is visible right next to the fighters. They are even seen moving. (01:23:45)