Plot hole: Greg suddenly wears Jack's "breast" during the "monkey business" scene with a crying LJ. But the only time we see it is in the RV which Jack would most likely have kept locked up. How did Greg get ahold of it?
Continuity mistake: Jack drops the two vials into the Tom Collins glass, while in the bathroom. At the hand-off, when he places the drink on the tray, there are no vials in the glass - there is no ice blocking them from view, just a skewer holding a maraschino cherry, a wedge of lemon, and a straw - no vials. Even Jack can't make the two vials invisible. (01:23:40)
Trivia: Near the start of the movie, when Greg & Pam are on the plane, the stewardess who asks Greg if he wants help with his case, is the same one that he shouted at near the end of the first movie.
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