Factual error: After the intruders flood the panic room with propane, Jody Foster's character gets a lighter and ignites the propane causing it to burn along the ceiling. This would be impossible as propane is heavier than air and would sink to the floor rather than rise up to the ceiling. Lighting a flame in that room should have caused anyone in the room and on the floor to be engulfed in flames almost instantly.
Other mistake: Near the end of the movie Dwight Yoakam is holding Jodie Foster's daughter captive as he tries to exit the house. Jodie Foster sneaks up behind him with a sledgehammer and swings it at his head. He turns to face her and the metal end of the hammer catches him firmly in his temple, knocking him down a flight of stairs. A few minutes later he comes up the stairs and tackles Jodie Foster to the ground, seemingly unhurt by the impact of the sledgehammer.
Factual error: The mother tells the daughter to keep warm and drink water. In fact that would lower the blood sugar faster. This method is used for high blood sugar to lower it back to normal.
Factual error: The portrayal of Sarah's type-1 diabetes is loaded with inaccuracies. We saw her eating pizza the previous evening and along with this any sensible diabetic would have injected herself with enough insulin to last through the night, to cope with the sugars in the food she'd eaten. But in the panic room just a few hours later, she apparently needs another dose - wrong. If her condition was due to stress, she would have needed sugar or a glycogen injection, not insulin. In response Meg searches for sugary food to give Sarah. That's correct, but next thing Meg wants to inject Sarah with insulin, which would kill any diabetic in such a state. Finally, when becoming hypoglycemic Sarah thrashes about, apparently having an epileptic fit instead of what would really happen - she would just become very sleepy, lose consciousness and go into a coma. All this demonizes diabetes into a convenient scary plot device but in reality the condition is quite mundane - typical Hollywood.
Continuity mistake: During the first meal in the new house, the level of Coke in the daughter's glass keeps changing as the camera cuts between her and her mother. The Coke can revolves as well. Sometimes the Coke-logo is visible, at other times the list of ingredients is facing the audience.
Audio problem: When Jodie Foster first hears a ring at the front door, Steven says, "The police." and Jodie says, "You called the police?" He responds with, "Of course I did. You scared the s*** out of me." When he says, "You scared the s*** out of me.", his mouth movement does not match what we hear.
Continuity mistake: When Meg and Sarah are inspecting the house in the beginning of the film, Sarah's bag has pawprints on it in the first shot. In the second shot the pawprints change to faces.
Factual error: You would never give insulin to someone with low blood sugar. It would kill them. (02:53:12 - 02:54:00)
Continuity mistake: The girl is inside the room with Forrest Whitaker and the other guy, about the time Whitaker picks up the red thing with the needle, watch the loose hair on the right side of her head, close to her ear: It keeps moving up, down, sometimes is wetter, sometimes dryer. And the girl barely moves.
Factual error: In the scene where Kristen Stewart is flashing SOS in morse code through the hole her mother asks "where did you learn that" she then replies "Titanic." In the movie 'Titanic' they correctly used the proper distress signal of the time which was actually CQD (CQ is Code for 'All Stations' and suffixed by 'D' for distress). CQD in Morse code is -.-. -.- -..
Factual error: When the burglars use the crowbar to break through the roof hatch, the security system display changes from "System Armed" to "Zone 19 Disabled" which can only occur when the zone is disabled by the user. Additionally, the alarm should have sounded immediately when the sensor on the hatch was broken. If the circuit had already been disabled then the security system would not have reacted by saying "Zone 19 Disabled."
Continuity mistake: When Junior is shot in the head, the original bullet wound is almost exactly between the eyes, but when you see him lying on the floor, the bullet wound is over his right eye
Other mistake: According to the cops at the door, Meg's husband revealed to them that Meg said "There are three" on the phone before the line was cut off. However, earlier in the film during the call, Meg said "There are three men..." and then the line was cut by Burnham. The husband would have heard the word "men" as well to give to the cops.