Revealing mistake: When Blade is being put into the chamber so they can siphon his blood, there are straps for his neck and his wrists. He is placed into the chamber and his hands are placed in the wrist restraints, no one reaches for the neck restraint. In the next scene, the strap is around his neck.
Revealing mistake: When Traci Lords approaches Blade, he tries to shoot her with the shotgun only for it to click, empty. He then proceeds to impale her with the silver stakes mounted in the end of his gun. If you look closely (probably more noticeable in full screen), you can still see the tips on the end of his stakes when she hisses at him, meaning that they're not actually inside her, even though she disintegrates in the next shot as if they were.