Plot hole: In any given volume of air, there are any number of tiny, living organisms; dust mites, viruses, bacteria, etc. Why did the teleporter combine Seth's DNA only with the fly that was in the chamber? If he had taken the "floating organisms" into account in his calculations and programming, then why would he not have excluded ALL foreign DNA?

The Fly (1986)
Plot summary
Directed by: David Cronenberg
Starring: Geena Davis, Jeff Goldblum, John Getz, Joy Boushel
Dr. Brundle (Jeff Goldblum) invents a teleporting machine, then tries it on himself. Unfortunately a fly enters the transportation chamber with him and in the process their genes got mixed.
Brundle's body and mind start to change -- he is a lot more powerful than before, he can think better and faster, but then he begins to transform into something he later name 'Brundlefly' -- he loses nails, then teeth,
His girlfriend (Geena Davies) is pregnant but she doesn't know whether it's a Brundle or a Brundlefly baby, so she wants an abortion. The Brundlefly kidnaps her right from the operation table.
Seth Brundle: I think you're making a mistake. I think you really want to talk to me.
Ronnie: Sorry, I have three other interviews to do before this party's over.
Seth Brundle: Yeah, but they're not working on something that'll change the world as we know it.
Ronnie: They say they are.
Seth Brundle: Yeah, but they're lying. I'm not.
Question: Well into the movie, Seth's computer, which uses voice recognition, can no longer recognize his voice due to his transformation. How then, did he hook up the three telepods and execute the final sequence if he couldn't get into his computer?
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Chosen answer: He just used the keyboard. We see him typing on it several times before this scene, so the computer is not voice command only.
Grumpy Scot