Trivia: Spider-Man asking Doctor Strange to cast a spell in order to make people forget that he is Peter Parker is similar to the comics storyline "One More Day." After the events of "Civil War" where Spider-Man revealed his secret identity to the world, he made a deal with Mephisto to save Aunt May's life in exchange for Mephisto nullifying Peter's marriage to Mary Jane Watson. As part of the deal, Mephisto erased everyone's memory of Spider-Man being Peter Parker.
Trivia: !MASSIVE SPOILER ALERT! YOU HAVE BEEN WARNED!"Spider-Man: No Way Home" features the first on-screen appearance of Tobey Maguire's Spider-Man in 14 years, since the release of "Spider-Man 3" in 2007. It also features the first on-screen appearance of Andrew Garfield's Spider-Man in 7 years, since the release of "The Amazing Spider-Man 2" in 2014. The film's multiverse-based story allowed them to return and interact with one-another and Tom Holland's version of the character.
Trivia: !SPOILERS! Despite their prominent appearances in the film, being featured in most of the third act in multiple major sequences, Tobey Maguire and Andrew Garfield were actually only on-set for a surprisingly short two weeks. For reference, filming for the entire movie took just over five months, meaning they were on-set for less than 10% of the total shoot.
Trivia: SPOILER: Prior to the film's release, unconfirmed reports stated Charlie Cox would appear in the film as Matt Murdock, reprising his role from the Netflix series Daredevil. Marvel Studios President Kevin Feige practically spilled the beans days before the release, stating that if the day ever came that Marvel would use the Daredevil character in their films, Cox would be playing him. The episode of Hawkeye that premiered the day before this film's release all but confirmed this, as Vincent D'Onofrio was revealed to be reprising his role as Kingpin from the aforementioned Daredevil series.
Trivia: !SPOILERS! Tobey Maguire and Andrew Garfield gave a lot of notes on their characters, which the writers gratefully accepted. For example, Maguire didn't want too much revealed about what's been happening with his Peter, aside from the fact that he was still with Mary Jane. (Presumably to leave his adventures up to the fans' imaginations.) And Garfield wanted his Peter to be a bit more ferocious/emotional compared to his first two films to show how Gwen Stacey's death changed him.
Trivia: Spoiler Alert: When Sandman and Lizard are cured and turned back into humans, the footage of them in their human forms is actually digitally manipulated stock footage and alternate takes from their respective original films. Ex. When Sandman turns human, it's using manipulated stock footage from the subway fight scene in "Spider-Man 3." When Lizard is turned human, it appears to be an alternate angle/B-roll from footage featured in the final battle of "The Amazing Spider-Man."
Trivia: Following the release of the film, Guinness World Records recognized Tobey Maguire and Willem Dafoe as having the longest careers portraying live-action Marvel characters, clocking in at 19 years and 225 days, surpassing the 16 years and 232 days record previously held by Hugh Jackman and Patrick Stewart for their respective roles of Wolverine and Charles Xavier from the X-Men franchise.
Trivia: Before the release of this film, the original 2002 "Spider-Man" movie was still the highest grossing solo-Spider-Man film domestically at $407 million, and had been for nearly 20 years. It was finally surpassed by this film on only its ninth day of release. (And this is despite being released during the pandemic when the box office was generally underperforming).