Continuity mistake: When the female nurse is in her 4x4 vehicle, she looks in her mirror and sees two fire trucks. In the far away shot the first fire engine overtakes her, then when it cuts back to her it's overtaking her again. (00:34:30)
Factual error: The volcanic ash that can be seen throughout the film is too big to be real. The ash shown is something like 1-2 cm in diameter. Volcanic ash is not that big in real life; it is not more than 2 millimetres in diameter. (01:02:30)
Character mistake: When they're literally watching lava creep down the street Roark says "whatever this stuff is" (something like that). 2 things: 1) how does he not realise it's lava, and 2) although it's weird to have lava in LA, Amy already told him that lava could push through from the tar pits, so he should have been able to figure it out.