Continuity mistake: During the truck scene, when the truck has just come off the bridge, notice the sign on the right hand side says "24 hours." Seconds later the sign seems to have mysteriously disappeared.
Factual error: While escaping Pescadero, Sarah breaks Dr. Silberman's left arm with a baton as he reaches for the phone. Moments later, when Sarah is holding Dr. Silberman "hostage" by sticking the syringe of cleaner fluid, he opens the security doors (which are extremely heavy) with the same left arm. This would be virtually impossible and downright excruciating.