Thanos pulls the final infinity stone from Vision's head, seemingly killing him. He completes the gauntlet - Thor throws his new axe Stormbreaker at Thanos' chest, seriously wounding him but not enough to stop him snapping his fingers. Half the universe is wiped from existence, with various Avengers fading to nothing, including Black Panther, Bucky, Drax, Groot, Mantis, Scarlet Witch, Spider-Man, Peter Quill, and Dr. Strange. Before he fades, Strange is asked by Tony Stark why he'd give away the time stone, and he says "it was the only way", presumably referring to the one in many millions of outcomes he'd foreseen where they eventually win, regardless of current losses. Thanos teleports to a peaceful planet and seems happy with a job well done. The post-credits scene shows Nick Fury and Maria Hill were both also disintegrated, with Fury managing to send one last message to Captain Marvel before he disappears, uttering "motherf..."
Jon Sandys ★
Answer: "Doctor Strange" demonstrates that the Infinity Stones are useful in the most dire of situations, when Strange used the Time Stone to prevent Dormammu from taking over the Earth. It's also possible that some of the stones are indestructible. Wanda is able to temporarily destroy the Mind Stone by using her own powers, but the Power Stone will destroy any being that doesn't possess the strength to wield it, and the Reality Stone is shown to have a will of its own and defended itself when it bonded with Jane Foster.
Phaneron ★
Also, in the comics, if the stones are destroyed they will simply be replaced by something else or even stones again. They represent the existence of the universe and cannot be destroyed for real. Always only temporarily.
lionhead