Continuity mistake: In the washroom scene, in between Gene Wilder saying "That's humorous" and "May I speak", Richard Prior is applying the shoe polish on Gene Wilder's forehead and not the nose, but next shot facing Wilder, there is no polish on Wilder's forehead but there is polish on his nose. (01:14:25)
Continuity mistake: When Devereaux is shot by the cop in the helicopter, he's alone in the Silver Streak's engine compartment, leaning out the open door. He's then hit by an oncoming engine. In later shots of the runaway train, there's no sign of his body or of any blood, and the door has somehow closed itself. (01:44:00)
Continuity mistake: In the train crash sequence, the real locomotive's headlamp has two lights side by side. However, when the movie cuts to the model crashing into the terminal, the headlamp has a single light. The model also lacks grilles on either lower face which were present on the real locomotive. (01:48:00)
Continuity mistake: While the train crash scene takes place at the fictitious Chicago Central Station, it was filmed at Toronto's Union Station in a discontinuous sequence. The train enters the station shed from the west, followed by a cab view filmed at the east end of the station. Finally, an exterior shot of the train inside the shed is shown, once again at the west end.