Continuity mistake: When Vanessa takes off Wade's mask at the end of the movie, he has a picture of Hugh Jackman's face stapled to his. When Vanessa removes the picture, the staple on Wade's chin is affixed and horizontal. In the next shot, it's hanging down. The third time we see it, it's back to position 1.
Continuity mistake: When the glass chamber holding Vanessa falls off the deck at the end it falls top first, but when the concrete block is lifted off, not only is it the right way up, but it is also at a right angle to the way it fell.