Continuity mistake: When Marty confronts George as "Darth Vader", after George asks "who are you?" Marty plays the music again, and George presses his hands to his ears. In the shot from behind, his hands are cupped around his ears, in a very different position. Then when Marty says "silence earthling", in the shot from the front his hand is away from his ear entirely.
Continuity mistake: When Marty is on a skateboard being chased around the town square by Biff and his friends, he grabs the back end of a truck. After the truck makes a right turn, notice how the two kids he initially stopped to get a skateboard from at the beginning of the scene suddenly appear standing at the street corner between shots, holding their wooden crates. (01:06:25)
Character mistake: In the parking lot when Marty begins to film, Doc says the date and exact time according to his watch. Marty then looks at his watch. Apparently his is off because he shakes his wrist and puts the watch to his ear to see if it is still working. However, he is wearing a digital watch which wouldn't tick or likely have broken parts to rattle.
Continuity mistake: When Marty drives out of the Peabody barn after arriving in 1955, it's night, or certainly pre-dawn - the sky is very dark from every angle when he's fired at while driving away. Next shot he drives past the "Peabody ranch" sign onto the main road and it's significantly brighter, with the sun rising over the horizon. Then when he notices the Lyon Estates sign shortly afterwards it's broad daylight - judging from the length of the shadows the sun's very high in the sky. Lyon Estates isn't that far from Twin/Lone Pine(s) mall.