Factual error: Trevor - a Professor of Geology - boasts about having an article published in Scientific American, and that is not something any scientist would do. Scientific American is looked upon with slight disdain by the scientific community, considered to be a populist crowd pleaser. It is not even peer reviewed. Considering that he has just turned the geological and archaeological worlds on their heads he would have been better off publishing in Journal of Geological Research or Geology, both prestigious professional journals.
Continuity mistake: At the beginning when Indy is talking to Spalko, his hands keep alternating from being in his pockets to just resting at his sides between shots.
Factual error: Basic physics - Hancock throws Michel from a dead stop to above cloud level in about eleven seconds. The clouds are bog standard cumulus which form at around 7,000 metres in temperate zones. This means that Michel accelerates to about 700 metres per second instantly, from a dead stop. Obviously he cannot accelerate during his ascent, so his starting speed has to be at least that. (In fact he would have to start his ascent much, much faster than 700 metres per second as he would be constantly decelerating due to gravity and air resistance, but it will do as a start point.) Michel accelerates from 0 to 2,520 kilometres per hour - twice the speed of sound - in zero seconds. He would be accelerating at around 5000 Gs, turning him into a very long streak of fine, pink mist.
Plot hole: At the start of the movie, a great deal is made of the boom mic that enters the shot. This is ridiculous, because Bolt's view would not be restricted to what was onscreen, he'd have a perfect view of the person holding the boom mic (as evidenced by it not being stable). There's no possibility of him not seeing the person holding the mic either. As Bolt completely and utterly believes the world he lives in, and thinks the situations he finds himself in (saving Penny) are real, someone holding a boom mic would break the illusion for him. In all instances in the movie where an outside force (i.e. a dog handler) interacts with him, Bolt never gets to see the person handling him (handler approaches from behind), the boom mic operator however is literally right in front of him.
Factual error: In one scene they are playing on an Xbox 360, but the Xbox 360 did not come out until 2005, and the game being played, Gears of War, wasn't released until 2006. The movie takes place in 2004.
Continuity mistake: At Riley's Garage, when Troy and Chad are about to rummage through the junk looking for the radiator cap, Troy raises his arms and his boxers are light grey, but next shot when he lifts the truck's hood his boxers are black. It's also noteworthy to mention that during "Boys Are Back," young Troy is wearing patterned boxers, though all other clothing is identical. (00:53:45)
Factual error: The moon is full every night the highschoolers are at the lake house.
Continuity mistake: When Seth has been sliced by the blade, he spits blood that goes all over his face. It then cuts to Hoffman looking at him, then back to Seth, and now the blood on his face has gone. This happens three or four times. (00:05:10)
Factual error: All the Cisco VoIP phones seen in the film have the booting Cisco logo on them and would not work due to no connection.
Factual error: During the boat chase scene, Bond throws a grappling hook/anchor from the old boat he is driving onto the deck of the rubber boat "riding" his. The rubber boat is then violently yanked off of Bond's boat and crashes. This makes no sense. For the rubber boat to be yanked off that way, the other end of the anchor line would have to be tied to something stationary. However, the other end of the line is just lying in Bond's boat. There's even a shot of it sitting there.