Continuity mistake: In the scene where Jonathan picks up the scarab, it breaks open and the beetle inside starts to crawl under his skin. We see Brendan Fraser tear Jonathan's shirt and cut the beetle out of him. However, in the very next scene, we see Jonathan walking into the temple, his shirt is intact and there is no blood to be seen. (01:37:05 - 01:38:30)
Visible crew/equipment: In a scene in a cave that is the lair of the "eaters of the dead," the camera takes an overhead wide angle shot of the "eaters" walking down into the cave. It is possible to see a young man wearing a burgundy t-shirt and beige shorts (a crew member), sitting against the wall of the cave cross-legged.
Continuity mistake: Close to the end when Edward Norton runs up to the front of the empty building and Brad Pitt appears, he tries to break the glass door by pushing a bench into the door, but it doesn't work. He doesn't move the bench and he then shoots at the glass and breaks it. When it shows him walking through the broken door, the bench has disappeared. (02:05:10)
Factual error: The priest says that St. John saw the number 666 in his vision, but it was actually 999 inverted. I'm not sure, but I don't believe St. John read modern Arabic numerals like we do. Didn't he read Roman numerals? I think if St. John saw the number 666, it would actually be DCLXVI. (01:05:40)